Evaluation of Striatal Dopamine Transporter Density using 123I-beta-CIT SPECT in Schizophrenic Patients Treated with Olanzapine - Pilot study / 대한핵의학회잡지

No abstract available.

One-year Follow-up of the Hospitalized Schizophrenic Patients Treated with Risperidone or Olanzapine: Aspects in Cost Economy / 신경정신의학

OBJECTIVES: This study was conducted to access the cost-effectiveness of risperidone or olanzapine in a subset of patients with schizophrenia. METHODS: Two schizophrenia patient groups who were with risperidone(n=17) or olanzapine(n=20) were compared with each other in total medical cost, average daily cost of antipsychotics, discharge rate, drop-out rate, readmission rate and extropyramidal side effect(EPS). RESULTS: The average daily costs of risperidone and olanzapine treated groups were \9,778 and \9,536 in admission, and \2,219 and \5,118 in patients one year after discharge respectively. Risperidone group showed higher rate of EPS than olanzapine group. There was no significant difference in discharge or drop-out rate. CONCLUSIONS: Olanzapine group had higher total daily medical cost and daily medication cost, while risperidone group showed higher readmission and EPS rate.

Three Cases of Systemic Lupus Erythematosus with Severe Psychotic Symptoms / 신경정신의학

Systemic lupus erythematosus(SLE) is a disease of unknown etiology in which multiple organs are damaged by pathogenic autoantibodies and immune complexes. Neuropsychiatric manifestations in SLE were first described by Kaposi in 1872. These are so diverse that they include psychosis, depression, stroke, seizure and cognitive dysfunction etc. These patients are frequently consulted for psychiatric evaluation. Neuropsychiatric manifestations in SLE are also among the leading causes of morbidity and mortality and associated with poor long-term outcome. So it is essential to recognize and intervene these symptoms early. But the clear diagnostic criteria for CNS involvement in SLE have not been formulated, and diversity and fluctuation of illness make it difficult to confirm it. The authors reported three cases of SLE with severe neuropsychiatric manifestations. These patients showed symptoms such as disorientation, auditory and visual hallucibation, delusion and mood instability. They became frequently impulsive and violent and had risks to injure themselves or others. Although CNS involvement in SLE is not well known, we reviewed the pathogenesis, classification, diagnosis, clinical manifestation and treatment of them.

Polymorphism of CYP2D6*10B of Patients with Schizophrenia in Korean Population / 신경정신의학

OBJECTIVES: This study was done to compare the proportion of the CYP2D6*10 allele between previously reported data of normal Korean subjects and schizophrenic patients. And we investigated the relationship between the CYP2D6*10 allele and the clinical variables such as age of onset, duration of illness and psychopathology. METHODS: Total 82 DSM-IV Korean schizophrenic patients in monotherapy with risperidone participated in this study. The CYP2D6*10 allele which contains C188T mutation in exon 1 was identified by allele specific PCR amplification. We investigated the clinical variables such as age of onset and duration of illness through chart review. The baseline psychopathology with brief psychiatric rating scale (BPRS) before blood collection were done in clinically stable patients. RESULTS: Seventeen (20.7%) out of 82 patients were homozygous for CYP2D6*1, 22 (26.8%) for *10, while the remaining 43 patients (52.4%) were heterozygous for these alleles. These distributions were very similar with previously reported data of Korean normal subjects. There was no significant relationship between the CYP2D6*10 allele and the clinical variables such as age of onset, duration of illness and psychopathology. CONCLUSION: In Korean schizophrenic patients, there was no significant difference in CYP2D6*10 allele compared to normal Korean subjects.